North Pacific salmon (Oncorhynchus spp.) were collected during the winter 2022 Pan-Pacific International Year of the Salmon expeditions to the North Pacific high seas. Sampling was conducted using four vessels operating almost concomitantly between February 21 and April 18 across the study region: the NOAA research vessel Bell M. Shimada; R/V CCGS Sir John Franklin; R/V TINRO; and the F/V Northwest Explorer. Trawl nets were deployed at each station in the top 50 meters of the water column and towed for 60 minutes (night) or 90 minutes (day) at 4 to 5 knots. A 2x2 cm sample of salmon muscle tissue was collected from above the lateral line and in front of the dorsal fin and stored at -80°C. Whole liver was collected immediately post-mortem and stored at -20°C until processing. Muscle and liver samples were then processed in the laboratory at the University of British Columbia. Muscle tissue was lyophilized in freeze drier for 48 hours, whereas liver samples were oven-dried at 50°C for the same duration. Dried tissue was homogenized using mortar and pestle, encapsulated in tin (Sn) capsules, and sent for measurements of carbon and nitrogen stable isotope ratios and elemental contents at an external lab. Samples were analysed on an Elemental Analyser coupled to an Isotope Ratio Mass Spectrometer. The data reported includes each sample ẟ13C, %C, ẟ15N, % N, and CN ratios, in addition to the metadata associated with each sample (e.g., coordinates of oceanographic station and bottom depth where salmon specimen was collected, etc.).